the baseline and longitudinal changes of pcc connectivity in mild cognitive impairment a combined structure and resting-state fmri studypcc的基线和纵向变化连接在轻度认知障碍结合结构及静息状态功能磁共振成像研究.pdf

The Baseline and Longitudinal Changes of PCC Connectivity in Mild Cognitive Impairment: A Combined Structure and Resting-State fMRI Study 1. 1. 1 1 2 2 1 Zhiqun Wang , Peipeng Liang , Xiuqin Jia , Guangwei Jin , Haiqing Song , Ying Han , Jie Lu , Kuncheng Li1,3* 1 Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China, 2 Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China, 3 Key Laboratory for Neurodegenerative Diseases, Ministry of Education, Beijing, China Abstract The baseline and longitudinal changes of the posterior cingulate cortex (PCC) connectivity were assessed in order to clarify the neural mechanism of mild cognitive impairment (MCI). Twenty-eight right-handed subjects (14 MCI patients and 14 healthy elders) participated in this study. Clinical and neuropsychological examinations were performed on all the subjects. PCC functional connectivity was studied by examining the correlation between low frequency fMRI signal fluctuations in the PCC and those in all the other brain regions. Additionally, we traced all the MCI patients and compared their PCC connectivity in the initial stage and that in 3 years later. We also explored the relationship between the PCC functional connectivity strength and cognitive performances. Our results are as follows: Functional connectivity between the PCC and a set of regions is decreased in MCI patients. Most of these regions are within the default mode network (DMN). Three years later, the regions of superior frontal gyrus (SFG) and middle frontal gyrus (MFG) presented further decreased connectivity to the PCC in MCI. In addition, we also find enhanced fu