comparison of brief cognitive tests and csf biomarkers in predicting alzheimer’s disease in mild cognitive impairment six-year follow-up study比较简单的认知测试和脑脊液生物标志物在预测阿尔茨海默氏症在轻度认知障碍6年随访研究.pdf

Comparison of Brief Cognitive Tests and CSF Biomarkers in Predicting Alzheimer’s Disease in Mild Cognitive Impairment: Six-Year Follow-Up Study 1 1 1 1 2 Sebastian Palmqvist *, Joakim Hertze , Lennart Minthon , Carina Wattmo , Henrik Zetterberg , 2 1 1 Kaj Blennow , Elisabet Londos , Oskar Hansson ¨ 1 Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden, 2 Department of Psychiatry and Neurochemistry, Institute of ¨ Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden Abstract Introduction: Early identification of Alzheimer’s disease (AD) is needed both for clinical trials and in clinical practice. In this study, we compared brief cognitive tests and cerebrospinal fluid (CSF) biomarkers in predicting conversion from mild cognitive impairment (MCI) to AD. Methods: At a memory clinic, 133 patients with MCI were followed until development of dementia or until they had been stable over a mean period of 5.9 years (range 3.2–8.8 years). The Mini-Mental State Examination (MMSE), the clock drawing test, total tau, tau phosphorylated at Thr (P-tau) and amyloid-b (Ab ) were assessed at baseline. 181 1–42 42 Results: During clinical follow-up, 47% remained cognitively stable and