curcumin loaded-plga nanoparticles conjugated with tet-1 peptide for potential use in alzheimers disease姜黄素loaded-plga纳米颗粒与tet-1肽共轭潜在的用于阿尔茨海默氏症.pdf

Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer’s Disease 1 1 1 1 1 Anila Mathew , Takahiro Fukuda , Yutaka Nagaoka , Takashi Hasumura , Hisao Morimoto , Yasuhiko 1 1 2 1 Yoshida , Toru Maekawa , Kizhikkilot Venugopal , D. Sakthi Kumar * 1 Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan, 2 Department of Respiratory Medicine, Sooriya Hospital, Chennai, India Abstract Alzheimer’s disease is a growing concern in the modern world. As the currently available medications are not very promising, there is an increased need for the fabrication of newer drugs. Curcumin is a plant derived compound which has potential activities beneficial for the treatment of Alzheimer’s disease. Anti-amyloid activity and anti-oxidant activity of curcumin is highly beneficial for the treatment of Alzheimer’s disease. The insolubility of curcumin in water restricts its use to a great extend, which can be overcome by the synthesis of curcumin nanoparticles. In our work, we have successfully synthesized water-soluble PLGA coated- curcumin nanoparticles and characterized it using different techniques. As drug targeting to diseases of cerebral origin are difficult due to the stringency of blood-brain barrier, we have coupled the nanoparticle with Tet-1 peptide, which has the affinity to neurons and possess retrograde transportation properties. Our results suggest that curcumin encapsulated-PLGA nanoparticles are able to destroy amyloid aggregates, exhibit anti- ox