cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community认知缺陷与额叶和颞叶白质病变中年人生活在社区.pdf

Cognitive Deficits Are Associated with Frontal and Temporal Lobe White Matter Lesions in Middle-Aged Adults Living in the Community 1,2 1 1 1 1 3,4 David Bunce *, Kaarin J. Anstey , Nicolas Cherbuin , Richard Burns , Helen Christensen , Wei Wen , Perminder S. Sachdev3,4 1 Centre for Mental Health Research, Australian National University, Canberra, Australian Capital Territory, Australia, 2 Department of Psychology, Brunel University, London, United Kingdom, 3 Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia, 4 School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia Abstract Background: The association between brain white matter lesions and cognitive impairment in old age is well established. However, little is known about this association in midlife. As this information will inform policy for early preventative healthcare initiatives, we investigated non-periventricular frontal, temporal, parietal and occipital lobe white matter hyperintensities (WMH) in relation to cognitive function in 428 (232 women) community-dwelling adults aged 44 to 48 years. Results: Frontal white matter lesions were significantly associated with greater intraindividual RT variability in women, while temporal WMH were associated with face recognition deficits in men. Parietal and occipital lobe lesions were unrelated to cognitive performance. These findings did not differ when education and a range of health variables, including vascular risk factors, were taken into account. Conclusion: Gender differences in WMH-cognition associations are discussed, and