biological characterization of cynara cardunculus l. methanolic extracts antioxidant, anti-proliferative, anti-migratory and anti-angiogenic activities生物特征cynara cardunculus l . methanolic提取抗氧化剂,anti-proliferative,anti-migratory和抗血管生成活动.pdf

Agriculture 2012, 2, 472-492; doi:10.3390/agriculture2040472 OPEN ACCESS agriculture ISSN 2077-0472 /journal/agriculture Article Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities Zélia Velez 1,2,*, Marco A. Campinho 1, Ângela R. Guerra 2,3, Laura García 2, Patricia Ramos 2,3, Olinda Guerreiro 2,3, Laura Felício 2, Fernando Schmitt 4,5 and Maria Duarte 2,3 1 Center for Marine Sciences (CCMAR), Universidade do Algarve Campus de Gambelas, 8005-139 Faro, Portugal; E-Mail: macampinho@ualg.pt 2 Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal; E-Mails: angela.guerra@cebal.pt (A.R.G.); lauraagp@ (L.G.); patriciaaramos@ua.pt (P.R.); olinda.guerreiro@cebal.pt (O.G.); lauraguerrafelicio@sapo.pt (L.F.); fatima.duarte@cebal.pt (M.D.) 3 Centre for Research in Ceramics Composite Materials (CICECO), University of Aveiro, 3810-193 Aveiro, Portugal 4 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), University of Porto, 4200-465 Porto, Portugal; E-Mail: fschmitt@ipatimup.pt 5 Department of Pathology and Oncology, Medical Faculty of University of Porto, 4200-319 Porto, Portugal * Author to whom correspondence should be addressed; E-Mail: zvelez@ualg.pt; Tel.: + 351-289-800-051; Fax: + 351-289-800-069. Received: 12 October 2012; in revised form: 12 November 2012 / Accepted: 10 December 2012 / Published: 19 December 2012 Abstract: