the effect of antioxidant supplementation on fatigue during exercise potential role for nad+(h)补充抗氧化剂在疲劳的影响运动对nad +潜在作用(h).pdf

Nutrients 2010, 2, 319-329; doi:10.3390/nu2030319   OPEN ACCESS   nutrients ISSN 2072-6643 /journal/nutrients Article The Effect of Antioxidant Supplementation on Fatigue during + Exercise: Potential Role for NAD (H) John Mach 1, Adrian W. Midgley 2, Steve Dank 3, Ross S. Grant 1,4 and David J. Bentley 5,* 1 School of Medical Science, University of New South Wales, Kensington, 2052, Australia; E-Mail: John.mach@.au (J.M.); r.grant@.au (R.S.G.) 2 Department of Sport, Health and Exercise Science, University of Hull, Hull, HU6 7RX, UK; E-Mail: A.W.Midgley@hull.ac.uk 3 Department of Pharmacology, University of Sydney, Sydney, 2006, Australia; E-Mail: steve.dank@ 4 Australasian Research Institute, Sydney Adventist Hospital, Sydney, 2076 Australia; 5 Health and Exercise Science, University of New South Wales, Kensington, 2052 Australia * Author to whom correspondence should be addressed: E-Mail: david.bentley@.au. Received: 19 January 2010; in revised form: 9 February 2010 / Accepted: 5 March 2010 / Published: 10 March 2010 Abstract: This study compared serum pyridine levels (NAD+ /NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway©). An increase of 17% in TTF was obse