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The Antioxidant, MnTE-2-PyP, Prevents Side-Effects Incurred by Prostate Cancer Irradiation 1. 2,3. 2 1 1 Rebecca E. Oberley-Deegan , Joshua J. Steffan , Kyle O. Rove , Kathryn M. Pate , Michael W. Weaver , 4,5 6 6 2 1 Ivan Spasojevic , Barbara Frederick , David Raben , Randall B. Meacham , James D. Crapo , Hari K. Koul2,3,7* 1 Pulmonary Division, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America, 2 Program in Urosciences, Division of Urology, Department of Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, 3 Denver Veterans Administration Medical Center, Denver, Colorado, United States of America, 4 Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, 5 PD/PD Bioanalytical Core Laboratory, Duke Cancer Institute, Durham, North Carolina, United States of America, 6 Radiation and Cancer Biology Division, Department of Cancer Biology, University of Colorado Health Sciences Center, Aurora, Colorado, United States of America, 7 University of Colorado Comprehensive Cancer Center, Aurora, Colorado, United States of America Abstract Prostate cancer is the most commonly diagnosed cancer, with an estimated 240,000 new cases reported annually in the United States. Due to early detection and advances in therapies, more than 90% of patients will survive 10 years post diagnosis and treatment. Radiation is a treatment option often used to treat localized disease; howe