红花黄色素治疗老年不稳定型心绞痛的疗效观察和预后影.doc

红花黄色素治疗老年不稳定型心绞痛的疗效观察和预后分析 王成军 蔡智荣 毛拥军 周珊珊 （青岛大学医学院附属医院特需保健科，青岛，266003） [摘要]目的 研究红花黄色素对老年不稳定型心绞痛(UAP)患者的临床疗效和预后影响。 方法 选取104例UAP的老年患者随机分为对照组(54例)和治疗组(54例)，对照组仅采用 常规治疗，治疗组在常规治疗的基础上给予红花黄色素，80mg静脉滴注，每日1次，均治疗2周，观察比较两组患者治疗前后心绞痛发作的频率、发作持续时间及硝酸甘油用量和心电图(ECG)变化，同时检测治疗前后c-反应蛋白(CRP)、肌钙蛋白T( CTnT)和D-二聚体(DD)的浓度。应用秩和检验、方差分析、t检验做统计学处理。结果 与对照组比较，临床疗效的差异有显著的统计学意义( P0.01)，而且治疗组的CRP、CTnT和DD的含量均有降低，无论与治疗前还是与对照组比较，差异均有统计学意义(P0.01~0.05)。结论 红花黄色素能够显著提高对老年UAP患者的临床疗效，而且改善预后。 [关键词] 红花黄色素 老年 不稳定型心绞痛 疗效 预后 [中图分类号] R541.4 [文献标识码]A [文章编号] Evaluation of effectiveness and analysis of prognosis of Safflow yellow in treatment of the geriatric patients with unstable angina pectoris WANG Cheng-jun; CAI Zhi-rong ；MAO Yong-jun；ZHOU Shan-shan (Geriatrics department, The affiliated hospital of Qingdao university medical college,Qingdao,266003,China) [ABSTRACT] OBJECTIVE: To evaluate the effectiveness and analyze the prognosis of Safflow yellow in treatment of the geriatric patients with unstable angina pectoris (UAP). MATHODS : In the study ,108 patients were randomly divided into treatment group(54 cases)and control group(54cases), the control group were treated with conventional therapy, based on it the treatment group administered Safflow yellow, after 2 weeks of treatment , to compare the duration and frequency of angina pectoris attacks, the consumption of nitroglycerin and the change of ECG around the therapeutic period. At the same time, c-reaction protein(CRP), troponin t(CTnT) and D-Dimer(DD) were detected before treatment and after treatment . Rank sum test, analysis of variance and t-test were adopted in statistical treatment. RESULTS Compared with the control group, there had significant difference in clinical effectiveness ( P0.01); the CRP,CTnT and DD in the treatment group were significantly decreased ( P0.05~ 0.01), but all the value had no difference in the control group(P0.05). CONCLUSION：