cord blood vα24-vβ11+ natural killer t cells display a th2-chemokine receptor profile and cytokine responses脐带血vα24-vβ11 +自然杀伤t细胞显示th2-chemokine受体和细胞因子反应.pdf

Cord Blood Va24-Vb11+ Natural Killer T Cells Display a Th2-Chemokine Receptor Profile and Cytokine Responses 1,5 2 5 5 3,4 Susanne Harner , Elfriede Noessner , Korinna Nadas , Anke Leumann-Runge , Matthias Schiemann , 5 6 1,5 Fabienne L. Faber , Joachim Heinrich , Susanne Krauss-Etschmann * ¨ 1 Comprehensive Pneumology Center, Ludwig-Maximilians University Hospital and Helmholtz Zentrum Munchen, Großhadern, Germany, 2 Institute of Molecular ¨ Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Großhadern, Germany, 3 Institute of Medical Microbiology, Immunology ¨ and Hygiene, Technical University Munich, Munich, Germany, 4 Clinical Cooperation Group ‘‘Immune-Monitoring’’, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany, 5 Children’s Hospital of the Ludwig-Maximilians University, Munich, Germany, 6 Institute of Epidemiology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg, Germany Abstract Background: The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established. Natural killer T (NKT) cells are a rare subset of T ce