大肠杆菌K1侵袭血脑屏障的研究进展.pdf

2017 44 3 686691 China A nim al H usbandry Vete r inary M e d ic ine doi cnki j K 1 K K BM ECs BBB K BBB R A Research Advances in Escherichia coli K1 Penetration Across Bloodbrain Barrier LING Chen Z HANG Qiw en SONG Kang JIANG Jianun YAN Gen iang j q College of A nimal Science and Technology Shihez i Univ ersity Shihez i China The General Station o A nimal H usbandr and Veterinar Medicine o Div ision No o X in iang f y y f f j Production and Construction Corp s H ami China Abstract E coli K strain is a representative strain of neonatal sepsis and meningitis w hich cau ses disease by blood circulation to the brain T he molecular mechanism of E coli K that adhe ring and invading the brain microvascular endothelial cells BM ECs and cro ss the blood brain barrier BBB has been f ocused on by many scholars In this review w e f ocused on the gene reg ulation mechanism s and sig naling pathw ay of E coli K cro ssing the blood brain barrier to under stand the molecular mechanism of the inf ection caused by E coli and provide ref erence f or preven tion and treatment program s Key words Esche r ichia col i meningitis invasion human brain microvascular endothelial cells HBM ECs bloodbrain barrier central nerve Ex PEC sy stem CN S K K L is te r ia monocy togen