改善药物血脑屏障通透性方法研究进展.pdf

718 Med 军事医学2012年9月第36卷第9期MilSci，Vol36，No 9，Sep，2012 改善药物血脑屏障通透性方法的研究进展 崔冬雪 [摘要] 随着人口老龄化的加剧，神经系统疾病的发生率越来越高，而血脑屏障成为治疗神经系统疾病过程的一 道难题。血脑屏障既可以保护大脑不受外界有害物质的侵害，维持脑部内环境的稳定，同时也限制了药物进入脑 部发挥其治疗作用。本文概述了目前已被证实能改善药物血脑屏障通透性的方法，如化学修饰，制剂改造，联合用 药等，系统综述了有关提高药物血脑屏障透过率的恩路及研究方法的进展。 [关键词]血脑屏障；通透性 [中图分类号]R961 [文献标志码]A [文章编号]1674—9960(2012)09-0718-03。 in Advancesmethodsfor blood-brainbarrier drugspermeabilitythrough CU／Dong—x,lte of ofHebei Pharmacy，Xingtai Province，Xingtai，Hebei054000，China) (Department People’SHospital Withtheincreasein 7S life incidenceof disor- [Abstract] peopleaverageexpectancy，theincreasinglyhigh neurological dersandtheblood—brainbarrieris a inthetreatmentof disorders．Thebrainisadelicate becomingproblem neurological that fromharmful and can itself its organ efficientlyprotect compounds regulate precisely also not the thesaBlemechanismscan obstructintothebrainto their Me．Thisarticle reviewed drugs play therapeutic only confirmedmethodswhich theblood—brainbarrier of aschemical improve drugs，such permeability combination also theideasandmethodsfor the transformation，and expounded drug therapy，butsystematically increasing blood—brainbarr