comparison of muscle transcriptome between pigs with divergent meat quality phenotypes identifies genes related to muscle metabolism and structure猪的肉质量之间的肌肉比较转录组表型标识肌肉代谢相关基因和结构.pdf

Comparison of Muscle Transcriptome between Pigs with Divergent Meat Quality Phenotypes Identifies Genes Related to Muscle Metabolism and Structure 1,2 1,2 1,2 ´ ´ ´ 1,2 ´ ´ 1,2 Marie Damon *, Joanna Wyszynska-Koko , Annie Vincent , Frederic Herault , Benedicte Lebret ´ ´ ` 1 INRA, UMR1348 Physiologie, Environnement et Genetique pour l’Animal et les Systemes d’Elevage (PEGASE), Saint Gilles, France, 2 Agrocampus Ouest, UMR1348 ´ ´ ` Physiologie, Environnement et Genetique pour l’Animal et les Systemes d’Elevage (PEGASE), Rennes, France Abstract Background: Meat quality depends on physiological processes taking place in muscle tissue, which could involve a large pattern of genes associated with both muscle structural and metabolic features. Understanding the biological phenomena underlying muscle phenotype at slaughter is necessary to uncover meat quality development. Therefore, a muscle transcriptome analysis was undertaken to compare gene expression profiles between two highly contrasted pig breeds, Large White (LW) and Basque (B), reared in two different housing systems themselves influencing meat quality. LW is the most predominant breed used in pig industry, which exhibits standard meat quality attributes. B is an indigenous breed with low lean meat and high fat contents, high meat quality characteristics, and is genetically distant from other European pig breeds. Methodology/Principal Findings: Transcriptome analysis undertaken using a custom 15 K microarray, highlighted