targeting receptor tyrosine kinases for chemoprevention by green tea catechin, egcg化学预防的目标受体酪氨酸激酶绿茶儿茶素、儿茶素.pdf

Int. J. Mol. Sci. 2008, 9, 1034-1049; DOI: 10.3390/ijms9061034 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /ijms Review Targeting Receptor Tyrosine Kinases for Chemoprevention by Green Tea Catechin, EGCG Masahito Shimizu *, Yohei Shirakami and Hisataka Moriwaki Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan * Author to whom correspondence should be addressed; E-mail: shimim-gif@umin.ac.jp; Tel.: +81-(58) 230-6311; Fax: +81-(58) 230-6310; Received: 12 May 2008; in revised form: 4 June 2008 / Accepted: 4 June 2008 / Published: 20 June 2008 Abstract: Tea is one of the most popular beverages consumed worldwide. Epidemiologic studies show an inverse relationship between consumption of tea, especially green tea, and development of cancers. Numerous in vivo and in vitro studies indicate strong chemopreventive effects for green tea and its constituents against cancers of various organs. (–)-Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, appears to be the most biologically active constituent in tea with respect to inhibiting cell proliferation and inducing apoptosis in cancer cells. Recent studies indicate that the receptor tyrosine kinases (RTKs) are one of the critical targets of EGCG to inhibit cancer cell growth. EGCG inhibits the activ