targets and mechanisms of photodynamic therapy in lung cancer cells a brief overview光动力治疗在肺癌细胞靶点和作用机制简要概述.pdf

Cancers 2011, 3, 1014-1041; doi:10.3390/cancers3011014 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Targets and Mechanisms of Photodynamic Therapy in Lung Cancer Cells: A Brief Overview Angela Chiaviello †, Ilaria Postiglione † and Giuseppe Palumbo * Department of Biologia e Patologia Cellulare e Molecolare ―L.Califano‖- UniversitàFederico II, Via S. Pansini, 5 80131 Naples, Italy; E-Mails: angelachiaviello@libero.it (A.C.); ilariapostiglione@interfree.it (I.P.) † These authors contributed equally to this work. * To whom correspondance should be addressed; E-Mail: palumbo@unina.it; Tel.: + 39 081 7463249. Received: 31 December 2010; in revisedform: 20 February 2011 / Accepted: 1 March 2011 / Published: 3 March 2011 Abstract: Lung cancer remains one of the most common cancer-related causes of death. This type of cancer typically develops over a period of many years, and if detected at an early enough stage can be eliminated by a variety of treatments including photodynamic therapy (PDT). A critical discussion on the clinical applications of PDT in lung cancer is well outside the scope of the present report, which, in turn focuses on mechanistic and other aspects of the photodynamic action at a molecular and cellular level. The knowledge of these issues at pre-clinical levels is necessary to develop, check and adopt appropriate clinical protocols in the future. This report, besides providing general information, includes a brief overview of present experimental PDT and provides some non-exhau