curcumin updated molecular mechanisms and intervention targets in human lung cancer姜黄素更新在人类肺癌的分子机制和干预的目标.pdf

Int. J. Mol. Sci. 2012, 13, 3959-3978; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer Ming-Xiang Ye 1,†, Yan Li 2,†, Hong Yin 3,* and Jian Zhang 1,* 1 Department of Pulmonary Medicine, Detection Center of Tumor Biomarker, Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, China; E-Mail: mingxiangye@ 2 Department of Pulmonary Medicine, First People’s Hospital of Xi’an, 710032 Xi’an, China; E-Mail: huliyan1971@126.com 3 Department of Radiology, Medical Imaging Center, Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, China † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: yinhong@ (H.Y.); zhangjian197011@ (J.Z.); Tel./Fax : +86-29(H.Y.); Tel./Fax : +86-29(J.Z.). Received: 6 February 2012; in revised form: 5 March 2012 / Accepted: 15 March 2012 / Published: 22 March 2012 Abstract: Curcumin, a yellow pigment derived from Curcuma longa Linn, has attracted great interest in the research of cancer during the past decades. Extensive studies documented that curcumin attenuates cancer cell proliferation and promotes apoptosis in vivo and in vitro. Curcumin has been demonstrated to interact with multiple molecules and signal pathways, which makes it a poten