the biological role of pi3k pathway in lung cancer生物pi3k通路在肺癌中的作用.pdf

Pharmaceuticals 2012, 5, 1236-1264; doi:10.3390/ph5111236 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review The Biological Role of PI3K Pathway in Lung Cancer Evangelos G. Sarris 1, Muhammad W. Saif 2 and Kostas N. Syrigos 1,* 1 Oncology Unit GPP, 3rd Dept of Medicine, Sotiria General Hospital, University of Athens, Athens 11527, Greece; E-Mail: sarris_v@yahoo.gr 2 Experimental Therapeutics Program, Division of Hematology/Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA; E-Mail: wsaif@ * Author to whom correspondence should be addressed; E-Mail: ksyrigos@med.uoa.gr; Tel.: +30-210-770-0220; Fax: +30-210-778-1035. Received: 27 September 2012; in revised form: 7 November 2012 / Accepted: 14 November 2012 / Published: 20 November 2012 Abstract: Lung cancer is the primary cause of cancer-related mortality worldwide and although improvements in treatment have been achieved over the last few years, long-term survival rates for lung cancer patients remain poor. Therefore, there is an imperative need for molecularly targeted agents that will achieve long-term disease control. Numerous downstream molecular pathways, such as EGF/RAS/RAF/MEK/ERK and PI3K/AKT/mTOR are identified as having a key role in the pathogenesis of various forms of human cancer, including lung cancer. PI3K/AKT/mTOR signal pathway is an important intracellular signal transduction pathway with a significant role in cell proliferation, growth, survival,