targeted therapy of cancer using photodynamic therapy in combination with multi-faceted anti-tumor modalities使用光动力治疗癌症的靶向治疗结合多方面的抗肿瘤方法.pdf

Pharmaceuticals 2010, 3, 1507-1529; doi:10.3390/ph3051507 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Targeted Therapy of Cancer Using Photodynamic Therapy in Combination with Multi-faceted Anti-Tumor Modalities Malini Olivo 1,2,3,4,†,*, Ramaswamy Bhuvaneswari 1,†, Sasidharan Swarnalatha Lucky 1, 1 1 Nagamani Dendukuri and Patricia Soo-Ping Thong 1 National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore; E-Mails: dmsram@.sg (R.B.); Lucky.S.S@.sg (S.S.L.); Nagamani.P@.sg (N.D.); nmstsp@.sg (S-P.T.) 2 Singapore Bioimaging Consortium, Biomedical Sciences Institutes, 11 Biopolis Way, #02-02 Helios, 138667, Singapore 3 School of Physics, National University of Ireland, Galway, Ireland 4 Department of Pharmacy, National University of Singapore, No. 18 Science Drive 4, Block S4, 117543, Singapore † These two authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: dmsmcd@.sg; Tel: +65 Fax: 0065 Received: 3 March 2010; in revised form: 28 April 2010 / Accepted: 11 May 2010 / Published: 14 May 2010 Abstract: Photodynamic therapy (PDT) has emerged as one of the important therapeutic options in the management of cancer and other diseases. PDT involves a tumor-localized photosensitizer (PS), which when appropriately illuminated by visible light converts oxygen into cytotoxic reactive oxygen species (ROS), that attack key structural entities within the