arterial structure and function in mild primary hyperparathyroidism is not directly related to parathyroid hormone, calcium, or vitamin d原发性甲状旁腺功能亢进动脉结构和功能在温和不是直接关系到甲状旁腺素,钙,维生素d.pdf

Arterial Structure and Function in Mild Primary Hyperparathyroidism Is Not Directly Related to Parathyroid Hormone, Calcium, or Vitamin D 1,2 3 4 1,2 1,2 Margareta Ring *, Parastou Farahnak , Tomas Gustavsson , Inga-Lena Nilsson , Maria J. Eriksson , Kenneth Caidahl1,2 1 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, 2 Karolinska University Hospital, Stockholm, Sweden, 3 Department of Clinical ¨ Science and Education, Section of Surgery, Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden, 4 Chalmers University of Technology, Gothenburg, Sweden Abstract Objective: Elevated levels of calcium and parathyroid hormone (PTH), characteristics of primary hyperparathyroidism (PHPT), may be associated with cardiovascular morbidity and mortality in the general population. We evaluated the possible vascular effects of these risk factors in patients with mild PHPT by using standard methods and new imaging techniques. Design: A prospective case-control study. Subjects and Methods: Forty-eight patients with mild PHPT without any known cardiovascular risk factors were studied at baseline and at one year after parathyroidectomy (PTX) in comparison with 48 healthy age- and gender-matched controls. We measured biochemical variables, augmentation index (AIx), aortic pulse wave velocity (PWVao), radial (IMTrad) and common carotid artery (IMTcca) intima media thicknesses, and the grayscale median (IM-GSM) of the latter. Results: No significant differences were observed between PHPT patients and controls at baseline for AIx (28.6612.2 vs. 27.7612.8%), IMTrad (0.2716