targeting cell entry of enveloped viruses as an antiviral strategy针对细胞进入包膜病毒的抗病毒策略.pdf

Molecules 2011, 16, 221-250; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy Elodie Teissier, François Penin and Eve-Isabelle Pécheur * Institut de Biologie et Chimie des Protéines, UMR 5086, Université de Lyon, IFR 128 BioSciences Gerland-Lyon Sud, 69367 Lyon, France; E-Mails: e.teissier@ibcp.fr (E.T.); f.penin@ibcp.fr (F.P.) * Author to whom correspondence should be addressed; E-Mail: e.pecheur@ibcp.fr; Fax: +33 472 72 26 04. Received: 6 October 2010; in revised form: 16 December 2010 / Accepted: 24 December 2010 / Published: 30 December 2010 Abstract: The entry of enveloped viruses into their host cells involves several successive steps, each one being amenable to therapeutic intervention. Entry inhibitors act by targeting viral and/or cellular components, through either the inhibition of protein-protein interactions within the viral envelope proteins or between viral proteins and host cell receptors, or through the inhibition of protein-lipid interactions. Interestingly, inhibitors that concentrate into/onto the membrane in order to target a protein involved in the entry process, such as arbidol or peptide inhibitors of the human immunodeficiency virus (HIV), could allow the use of doses compatible with therapeutic requirements. The efficacy of these drugs validates entry as a point of intervention in viral life cycles. S