《外科学》周期性麻痹（英文）-教学课件（非AI生成）.ppt

PeriodicParalysis

周期性麻痹*Introduction

Periodicparalysisisagroupofchannelopathies（离子通道病）thatarerelatedtosodium/calciumchannel.Itischaracteristicofskeletalmusclesrelaxedparalysisofrepeatedattackanditattacksrapidlyeverytimeandrecoveryinshorttime.*EtiologyandPathogenesis

Theetiologyandpathogenesisofperiodicparalysisisnotfullyunderstoodbutisgenerallyattributedtoadefeatinpotential,possiblyautosomal（常染色体）dominantinheritanceinbothhypo/hyperkalium,normalserumkaliformsoffamilialperiodicparalysishavebeendocumented.*Inbothforms,attackstendtooccuronawakeningandduringrestfollowingexercise.Highcarbohydrate（碳水化合物）orsodiumintakemayparticipateanattackinpatientswiththehypokalimicform,whilefastingmayprovokeanattackinpatientswiththehyperkalimicform.*Themorbidityofthediseasemightberelatedtomyolemma（肌膜）electricpotentialhyper-polarization.Baseontheheredodiathesis（遗传素质）,whenthechangeofintramyocytepotassium（钾）concentrationdifferencecausepotentialhyper-polarizationofmyolemma,thechannelofsodiumioninthemyolemmaisheldup,andthetransmissionofneuromuscleisblocked.Theclinicalpictureismyasthenia（肌无力）.*Pathology

Musclebiopsy（活检）specimensobtainedduringanattackshowvacuoles（空泡）containingglycogen（糖元）andcarbohydrate.*ClinicalPicture

1.Lowserumpotassium:attackstage1)Symptom:1*Attacksoftenbeginintheageof20-40andarethemostfrequentinearlyadultlife2*Sex:malemorefemale*3*Time:Commonlytheyoftenstartintheearlymorningonawakening,afteraperiodofrestfollowingexertionorafteraheavycarbohydratemeal.Thelimbsandtrunkisthemainpositioninparaly