synthesis and physical characterization of 2-((e)-1-(3-((e)-1-(2-hydroxyphenyl)ethylideneamino)-2-methylphenylimino)ethyl)phenol合成和生理特征的2 -((e)1 -(3 -((e)1 -(2-hydroxyphenyl)ethylideneamino)2-methylphenylimino)乙基)苯酚.pdf

Molbank 2004 Molbank 2006, M455 /molbank/ Synthesis and Physical Characterization of 2-((E)-1-(3-((E)-1-(2-hydroxyphenyl)ethylideneamino)-2- methylphenylimino)ethyl)phenol a b* a b A. A. Jarrahpour *, A. F. Jalbout , S. Rezaei and B. Trzaskowski aDepartment of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran b Department of Chemistry, University of Arizona, Tucson, AZ 85721 USA Phone: +98 711 2284822, Fax: +98 711 2280926, email: aliasghar6683@ or jarrah@chem.susc.ac.ir *Author to whom correspondence should be addressed Received: 28 December 2005/ Accepted: 3 January 200 6 / Published: 22 January 2006 Abstract : In this paper we propose the synthesis of 2((E)1(3((E)1(2hydroxyphenyl) ethylideneamino)2methylphenylimino) ethyl) phenol. In addition to its synthesis we present AM1 and B3LYP/631G* calculations to characterize the physical properties of the molecule. Keywords: 2Hydroxyacetophenone, 2methyl1,3phenylenediamine, Schiff base, AM1, B3LYP Introduction: Schiff bases are important intermediates for the synthesis of various bioactive compounds [12]. Furthermore, they are reported to show a variety of biological activities including antibacterial [3], antifungal [4], anti mouse hepatitis virus (MHV) [5], inhibition of herpes simplex virus type 1 (HSV1) and adenovirus type