synthesis and physical characterization of 4-(anthracen-10-yl)-1-cyclohexyl-3-phenoxyazetidin-2-one as a new trans 2-azetidinone合成和生理特征的4 -(anthracen-10-yl)1-cyclohexyl-3-phenoxyazetidin-2-one作为一种新的反式2-azetidinone.pdf

M538 Synthesis and Physical Characterization of 4(anthracen10yl)... Molbank 2007, M538 /molbank/ Synthesis and Physical Characterization of 4(anthracen10yl)1 cyclohexyl3phenoxyazetidin2one as a ew Trans 2azetidinone *, a a b Aliasghar Jarrahpour , Mohammad azari , and Abraham F. Jalbout a Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran. b Department of Chemistry, University of Arizona, Tucson, AZ 85721 USA *Author to whom correspondence should be addressed. Tel: + 98 711 2284822; Fax: +98 711 2280926; Email: jarrah@susc.ac.ir Received: 3 January 2007 / Accepted: 19 January 2007 / Published: 31 May 2007 Keywords: 2Azetidinone, AM1, polycyclic aromatic imine. Abstract: In this paper we propose the synthesis of 4(anthracen10yl)1cyclohexyl3phenoxyazetidin 2one. In addition to its synthesis AM1 calculations to characterize the physical properties of the molecule is also presented. Introduction βlactam antibiotics have saved many lives since 1945 [1]. Apart from their clini al use, recent reports on the use of βlactams for purposes other than antibiotics are gaining attention. This fourmembered cycli amide has been extensively used for the synthesis of several biologically active heterocyclic compounds [2]. It has been established that Taxol can be prepared by a coupling rea tion between natural ba atin and suitably substituted hy