γδ t cells cross-link innate and adaptive immunity in mycobacterium tuberculosis infectionγδt细胞天然免疫与适应性免疫交联结核分枝杆菌感染.pdf

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2011, Article ID 587315, 11 pages doi:10.1155/2011/587315 Review Article γδ T Cells Cross-Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection Serena Meraviglia,1 Sary El Daker,2 Francesco Dieli,1 Federico Martini,2 and Angelo Martino2 1 Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universit`a di Palermo, 90134 Palermo, Italy 2 Laboratory of Cellular Immunology, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Via Portuense 292, 00149 Rome, Italy Correspondence should be addressed to Angelo Martino, angelo.martino@inmi.it Received 19 September 2010; Revised 27 November 2010; Accepted 9 December 2010 Academic Editor: Carl Feng Copyright © 2011 Serena Meraviglia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Protective immunity against mycobacterial infections such as Mycobacterium tuberculosis is mediated by interactions between specific T cells and activated antigen presenting cells. To date, many aspects of mycobacterial immunity have shown that innate cells could be the key elements that substantially may influence the subsequent adaptive host response. During the early phases of infection, innate lymphocyte subsets play a pivotal role in this context. Here we summarize the findings of recent investigations on γδ T lymphocytes and their role in tuberculosis immunity. 1. Introduction challenge. In this context, CD4 T lymphocytes differentiate