snprd typing of mycobacterium tuberculosis beijing strains reveals local and worldwide disseminated clonal complexessnprd输入北京结核分枝杆菌菌株显示本地和全球传播克隆复合物.pdf

SNP/RD Typing of Mycobacterium tuberculosis Beijing Strains Reveals Local and Worldwide Disseminated Clonal Complexes ¨ 1,2 1 1 1 3,4 Anita C. Schurch , Kristin Kremer , Amber C. A. Hendriks , Benthe Freyee , Christopher R. E. McEvoy , 5 6 3 3 2 Reinout van Crevel , Martin J. Boeree , Paul van Helden , Robin M. Warren , Roland J. Siezen , Dick van Soolingen1,6* 1Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, (CIb/LIS, pb 22), Bilthoven, The Netherlands, 2 Radboud University Nijmegen Medical Centre/NCMLS, Centre for Molecular and Biomolecular Informatics, Nijmegen, The Netherlands, 3 Department of Science and Technology, National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research, Medical Research Council Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, Cape Town, South Africa, 4 Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, 5 Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 6 Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre/University Lung Centre Dekkerswald, Nijmegen, The Netherlands Abstract The Beijing strain is one of the most successful genotypes of Mycobacterium tuberculosis worldwide and appears to be highly homogenous according to existing genotyping methods. To type Beijing strains reliably we developed a robust typing scheme using single nucleotide p