the guinea-bissau family of mycobacterium tuberculosis complex revisited结核分枝杆菌的几内亚比绍家庭复杂的重新审视.pdf

The Guinea-Bissau Family of Mycobacterium tuberculosis Complex Revisited 1,2 1 1 3,4 Ramona Groenheit , Solomon Ghebremichael , Jenny Svensson , Paulo Rabna , Raffaella 5,6 7 8 ´ 8 8 1,9 Colombatti , Fabio Riccardi , David Couvin , Veronique Hill , Nalin Rastogi , Tuija Koivula , Gunilla ¨ 9* Kallenius 1 Department of Preparedness, Swedish Institute for Infectious Disease Control, Solna, Sweden, 2 Department of Microbiology, Tumor and Cell Biology, Karolinska ´ ´ ´ Institutet, Stockholm, Sweden, 3 Laboratorio Nacional de Saude Publica, Bissau, Guinea-Bissau, 4 Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau, ` 5 Hospital ‘‘Raoul Follereau’’, Bissau, Guinea-Bissau, 6 Department of Pediatrics, Azienda Ospedaliera-Universita di Padova, Padova, Italy, 7 Department of Public Health, University of ‘‘Tor Vergata’’, Rome, Italy, 8 WHO Supranational TB Reference Laboratory, Tuberculosis and Mycobacteria Unit, Institut Pasteur de la Guadeloupe, Guadeloupe, France, 9 Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden Abstract The Guinea-Bissau family of strains is a unique group of the Mycobacterium tuberculosis complex that, although genotypically closely related, phenotypically demonstrates considerable heterogenei