tgf-β-mediated sustained erk12 activity promotes the inhibition of intracellular growth of mycobacterium avium in epithelioid cells surrogatestgf-β-mediated erk12活动促进抑制细胞内持续增长的鸟结核分枝杆菌类上皮细胞代理人.pdf

TGF-b-Mediated Sustained ERK1/2 Activity Promotes the Inhibition of Intracellular Growth of Mycobacterium avium in Epithelioid Cells Surrogates 1 2 ´ 1 ˜ 3 ´ Carolina L’Abbate , Ivone Cipriano , Elizabeth Cristina Perez-Hurtado , Sylvia Cardoso Leao , Celia 1 4 Regina Whitaker Carneiro , Joel Machado Jr. * ˜ ˜ 1 Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brasil, 2 Disciplina de Biologia do ´ ˜ ˜ Desenvolvimento, Departamento de Morfologia e Genetica, Universidade Federal de Sao Paulo, Sao Paulo, Brasil, 3 Disciplina de Microbiologia, Departamento de ˜ ˜ ˆ ´ Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brasil, 4 Departamento de Ciencias Biologicas, Campus de Diadema, ˜ ˜ Universidade Federal de Sao Paulo, Sao Paulo, Brasil Abstract Transforming growth factor beta (TGF- b) has been implicated in the pathogenesis of several diseases including infection with intracellular pathogens such as the Mycobacterium avium complex. Infection of macrophages with M. avium induces TGF- b production and neutralization of this cytokine has been associated with decreased intracellular bacterial growth.