synergistic role of c-myc and erk12 in the mitogenic response to tgfβ-1 in cultured rat nucleus pulposus cells原癌基因的协同作用和促有丝分裂的回应erk12 tgfβ-1在培养大鼠髓核细胞.pdf

Available online /content/10/6/R140 Vol 10 No 6 Open Access Research article Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells 1 1,2 1,2 Tomoko Nakai , Joji Mochida and Daisuke Sakai 1Division of Organogenesis, Research Center for Regenerative Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa, 259-1193, Japan 2Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa, 259-1193, Japan Corresponding author: Daisuke Sakai, daisakai@is.icc.u-tokai.ac.jp Received: 21 May 2008 Revisions requested: 1 Aug 2008 Revisions received: 29 Nov 2008 Accepted: 5 Dec 2008 Published: 5 Dec 2008 Arthritis Research Therapy 2008, 10:R140 (doi:10.1186/ar2567) This article is online at: /content/10/6/R140 © 2008 Nakai et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Although transforming growth factor 1 (TGF1) Results We found that TGF1 promoted proliferation and cell is known to be a potent inhibitor of proliferation in most cell cycle progression while reducing expression of the cyclin- types, it accelerates proliferation in certain mesenchymal cells, dependent kinase inhibitors p21 and p27, which are such as articular chondr