antitumor effect of malaria parasite infection in a murine lewis lung cancer model through induction of innate and adaptive immunity抗肿瘤效应刘易斯疟原虫感染的小鼠肺癌模型通过感应先天和适应性免疫.pdf

Antitumor Effect of Malaria Parasite Infection in a Murine Lewis Lung Cancer Model through Induction of Innate and Adaptive Immunity 1,3 1,3 1,3 1,3 1 1 1 Lili Chen , Zhengxiang He , Li Qin , Qinyan Li , Xibao Shi , Siting Zhao , Ling Chen , Nanshan Zhong2*, Xiaoping Chen1,3* 1 Center for Infection and Immunity, State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, 2 State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China, 3 CAS-FS Biotech and Pharmaceutical Center, Chinese Academy of Sciences, Foshan, China Abstract Background: Lung cancer is the most common malignancy in humans and its high fatality means that no effective treatment is available. Developing new therapeutic strategies for lung cancer is urgently needed. Malaria has been reported to stimulate host immune responses, which are believed to be efficacious for combating some clinical cancers. This study is aimed to provide evidence that malaria parasite infection is therapeutic for lung cancer. Methodology/Principal Findings: Antitumor effect of malaria infection was examined in both subcutaneously and intravenously implanted murine Lewis lung cancer (LLC) model. The results showed that malaria infection inhibited LLC growth and metastasis and prolonged the survival of tumor-bearing mice. Histological analysis of tumors from mice infected with malaria revealed that angiogenesis was inhibited, which correlated with increased terminal deoxynucleotidyl transferase-mediated (TUNEL) stainin