bk channels control cerebellar purkinje and golgi cell rhythmicity in vivobk通道控制小脑浦肯野和高尔基体内细胞的韵律性.pdf

BK Channels Control Cerebellar Purkinje and Golgi Cell Rhythmicity In Vivo 1,2 3 3 4 3 2,5 Guy Cheron , Matthias Sausbier , Ulrike Sausbier , Winfried Neuhuber , Peter Ruth , Bernard Dan , Laurent Servais1,6* ´ ´ 1 Laboratory of Electrophysiology, Universite Mons-Hainaut (UMH), Mons, Belgium, 2 Laboratory of Neurophysiology and Movement Biomechanics, Universite Libre de ¨ ¨ ¨ Bruxelles (ULB), Brussels, Belgium, 3 Department of Pharmacology and Toxicology, Institute of Pharmacy, Universitat Tubingen, Tubingen, Germany, 4 Institute of ¨ ˆ ´ Anatomy, University of Erlangen-Nurnberg, Erlangen, Germany, 5 Department of Neurology, Hopital Universitaire des Enfants Reine Fabiola, Universite Libre de Bruxelles ˆ ´ (ULB), Brussels, Belgium, 6 Department of child neurology, Hopital Robert Debre, Paris, France Abstract Calcium signaling plays a central role in normal CNS functioning and dysfunction. As cerebellar Purkinje cells express the major regulatory elements of calcium control and represent the sole integrative output of the cerebellar cortex, changes in neural activity- and calcium-mediated membrane properties of these cells are expected to provide impor