tetraethylammonium block of water flux in aquaporin-1 channels expressed in kidney thin limbs of henles loop and a kidney-derived cell line.四乙铵块水通量aquaporin-1渠道表达在肾脏瘦四肢亨利的循环和kidney-derived细胞系。.pdf

BMC Physiology BioMed Central BMC Physiology x 2002, 2 Research article Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henles loop and a kidney-derived cell line. 1,2 1 1 Andrea J Yool* , Olga H Brokl , Thomas L Pannabecker , 1 2,3 William H Dantzler and W Daniel Stamer Address: 1Dept of Physiology, University of Arizona College of Medicine, Tucson, Arizona, USA, 2Dept of Pharmacology, University of Arizona College of Medicine, Tucson, Arizona, USA and 3Dept of Opthalmology, University of Arizona College of Medicine, Tucson, Arizona, USA E-mail: Andrea J Yool* - ayool@; Olga H Brokl - obrokl@; Thomas L Pannabecker - pannabec@; William H Dantzler - dantzler@aruba .; W Daniel Stamer - dstamer@ *Corresponding author Published: 15 March 2002 Received: 22 October 2001 Accepted: 15 March 2002 BMC Physiology 2002, 2:4 This article is available from: /1472-6793/2/4 © 2002 Yool et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Aquaporin-1 (AQP1) channels are constitutively active water channels that allow rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated ion channels. Tetraethylammonium chloride (TEA; 0.05 to 10 mM) was shown