comparative study of domoic acid and okadaic acid induced - chromosomal abnormalities in the caco-2 cell line比较研究软骨藻酸和冈田酸诱导的染色体异常caco-2细胞系.pdf

Int. J. Environ. Res. Public Health 2006, 3(1), 4-10 International Journal of Environmental Research and Public Health ISSN 1661-7827 © 2006 by MDPI Comparative Study of Domoic Acid and Okadaic Acid Induced - Chromosomal Abnormalities in the CACO-2 Cell Line 1 1,2 2 1 3* Pinto-Silva Carvalho , R. Catia , Serge Moukha , William G. Matias and Edmond E. Creppy 1Department of Environmental Engineering - Toxicological Laboratory of the Federal University of Santa Catarina, Brazil Campus Universitário, Trindade, 88040-900, Brazil 2Unit of Mycology and Food Safety, National Institute of the Agronomic Research - INRA - Villenave d’Ornon, France. 3Department of Pharmaceutical Sciences - Toxicological Laboratory of the University of Bordeaux 2, France. *Correspondence to Dr. Edmond E. Creppy. Email: edmond.creppy@tox.u-bordeaux2.fr Received: 12 December 2005 / Accepted: 24 March 2006 / Published: 31 March 2006 Abstract: Okadaic Acid (OA) the major diarrheic shellfish poisoning (DSP) toxin is known as a tumor promoter and seems likely implicated in the genesis of digestive cancer. Little is known regarding genotoxicity and carcinogenicity of Domoic Acid (DA), the major Amnesic Shellfish Poisoning (ASP) toxin. Both OA and DA