critical involvement of the atm-dependent dna damage response in the apoptotic demise of hiv-1-elicited syncytiaatm-dependent dna损伤反应的关键参与凋亡的hiv-1-elicited合胞体.pdf

Critical Involvement of the ATM-Dependent DNA Damage Response in the Apoptotic Demise of HIV-1- Elicited Syncytia 1. 2. 1 ´ ´ 3 3 Jean-Luc Perfettini , Roberta Nardacci , Mehdi Bourouba , Frederic Subra , Laurent Gros , Claire ´ 1 1 4 2 5 6 Seror , Gwenola Manic , Filippo Rosselli , Alessandra Amendola , Peggy Masdehors , Luciana Chessa , 7 8 9 9 3 Giuseppe Novelli , David M. Ojcius , Jan Konrad Siwicki , Magdalena Chechlinska , Christian Auclair , ´ 10 ´ 11 5 2,12 1 Jose R. Regueiro , Hugues de The , Marie-Lise Gougeon , Mauro Piacentini , Guido Kroemer * 1 INSERM U848, Institut Gustave Roussy, Villejuif, France, 2 National Institute for Infectious Diseases ‘‘Lazzaro Spallanzani’’, Rome, Italy, 3 CNRS UMR 8113 LBPA, Ecole ´ Normale Superieure de Cachan, Cachan, France, 4 CNRS FRE2939, Institut Gustave Roussy, Villejuif, France, 5 Antiviral Immunity, Biotherapy and Vaccine Unit, Department of Infection and Epidemiology, Institut Pasteur, Paris, France, 6 II Faculty of Medicine, University of Rome ‘‘La Sapienza’’, Rome, Italy, 7 Department of Biopathology and Diagnosing Imaging, University of Rome ‘‘Tor Vergata’’, Rome, Italy, 8 School of Natural Sciences, University of California