产超超广谱β内酰胺酶革兰阴性杆菌的耐药表型及基因分析.pdf

．56． 中国抗生素杂志2011年1月第36卷第1期 1)01-0056-04 文章编号：1001·8689(201 产“超．超广谱”p．内酰胺酶革兰阴性杆菌的耐药表型及基因分析 余娴袁斌雷军‘ (川北医学院药物研究所，南充637007) 摘要：目的 首次分析本地区产超．超广谱B．内酰胺酶(Super-spectrum 状。方法 果筛选出的2株产SSBLs菌株(1株阴沟肠杆菌和1株大肠埃希菌)均表现为多莺耐药，仅对亚胺培南敏感。阴沟肠杆菌质粒编码 AmpC酶主要基凼型。 关键词：超．超广谱p．内酰胺酶；超广谱p．内酰胺酶；AmpC酶；质粒；耐药性；基因型 中图分类号：R378．2文献标识码：A ． Resistant and of phenotypegenotypeanalyses bacilli Gram-negative producing Yu BinandLeiJun Xian，Yuan SichuanMedical ofMateriaMedica，North (Institute College，Nanchong，637007) Abstract To the resistanceandthefeatureofmolecular of Objectiveinvestigatedrug epidemiologySuper- Bacilliinour l05cefoxitinand spectrum13-lactamase(SSBLs)．producingGram—negative hospital．Methods collectedfrom 2008toJune2009．SSBLs strains ceftazidime—resistantbacilliwere Gram．negative January producing werescreened three—dimensionaltestsand tests．Theresistant were byimproved plasmidconjugation phenotypes detected tests．PCR was to the ESBLsand identify bysusceptibilityamplificationapplied genotypes cloacaeandanEscherichia resistant TwOstrains anEnterobacter coli，were