the active metabolite of leflunomide, a77 1726, interferes with dendritic cell function的活性代谢物leflunomide a77 1726年,干扰树突状细胞的功能.pdf

Available online /content/7/3/R694 Vol 7 No 3 Open Access Research article The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function 1 2 3 4 4,5 Bernhard M Kirsch , Maximilian Zeyda , Karl Stuhlmeier , Johannes Grisar , Josef S Smolen , 1 2,5 1 6 Bruno Watschinger , Thomas M Stulnig , Walter H Hörl , Gerhard J Zlabinger and Marcus D Säemann1 1Department of Internal Medicine III/Clinical Divisions of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria 2Department of Internal Medicine III/Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria 3Ludwig Boltzmann Institute of Rheumatology, Vienna, Austria 4Department of Internal Medicine III/Clinical Division of Rheumatology, Medical University of Vienna, Vienna, Austria 5CeMM – Center of Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria 6Institute of Immunology, Medical University of Vienna, Vienna, Austria Corresponding author: Marcus D Säemann, marcus.saemann@meduniwien.ac.at Received: 16 Dec 2004 Revisions requested: 21 Jan 2005 Revisions received: 23 Feb 2005 Accepted: 1 Mar 2005 Published: 1 Apr 2005 Arthritis Research Therapy 2005, 7:R694-R703 (DOI 10.1186/ar1727) This article is online at: /content/7/3/R694 © 2005 Kirsch et al ; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attr