Neovasculature and circulating tumor cells dual-targeting nanoparticles for the treatment of the highly-invasive breast cancer-学术期刊.pdf

Biomaterials 113 (2017) 1e17 Contents lists available at ScienceDirect Biomaterials journal homepage: /l ocate/biomaterials Neovasculature and circulating tumor cells dual-targeting nanoparticles for the treatment of the highly-invasive breast cancer Jianhui Yao a, Jingxian Feng a, Xiaoling Gao b, Dan Wei c, Ting Kang a, Qianqian Zhu a, Tianze Jiang a, Xunbin Wei c, Jun Chen a, * a Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai, 201203, PR China b Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, PR China c State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, PR China a r t i c l e i n f o a b s t r a c t Article history: Antiangiogenesis therapy has been served as a potent cancer treatment strategy for decades, yet dis- Received 29 July 2016 rupting neovasculature would provoke tumor cells into invasive growth and result in distal metastasis. Received in revised form The basic cause of cancer metastasis can be traced down to the presence of circulating tumor cells (CTCs) 21 October 2016 which detach from primary tumor site and act as ‘seeds’. Epithelial cell adhesion molecule (EpCAM) is a Accepted 22 October 2016 Available online 22 October 201