combined hyperthermia and radiotherapy for the treatment of cancer结合高热和放疗治疗癌症.pdf

Cancers 2011, 3, 3799-3823; doi:10.3390/cancers3043799 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Combined Hyperthermia and Radiotherapy for the Treatment of Cancer 1 2 3 1, Punit Kaur , Mark D. Hurwitz , Sunil Krishnan and Alexzander Asea * 1 Department of Pathology, Scott White Hospital and the Texas AM Health Science Center, College of Medicine, Temple, TX 76504, USA; E-Mail: pkaur@ 2 Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center and Harvard Medical School, Boston, MA 02115, USA; E-Mail: mhurwitz@ 3 Department of Radiation Oncology, The University of Texas MD Anderson Medical Center, Houston, TX 77030, USA; E-Mail: skrishnan@ * Author to whom correspondence should be addressed; E-Mail: asea@ or aasea@; Tel: +1 (254) 743-0201; Fax: +1 (254) 743-0247. Received: 15 July 2011; in revised form: 23 September 2011 / Accepted: 23 September 2011 / Published: 30 September 2011 Abstract: Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success. Radiation therapy has become an integral part of modern treatment strategies for many types of cancer in recent decades, but is associated with a risk of long-term adverse effects. Of these side effects, cardiac complications are particularly relevant since they not only adversely affect qua