Structural And Functional Changes Of The Duodenum In Human Norovirus Infection-学术期刊.pdf

Downloaded from / on June 1, 2015 - Published by Small intestine Structural and functional changes of the duodenum in human norovirus infection H Troeger,1 C Loddenkemper,2 T Schneider,1 E Schreier,3 H-J Epple,1 M Zeitz,1 M Fromm,4 J-D Schulzke1 1 Department of ABSTRACT techniques allows rapid testing for infection in Gastroenterology, Infectious Background: Norovirus infection is the most frequent stool samples or vomitus, and is considered as gold Diseases and Rheumatology, cause of infectious diarrhoea in the western world. This standard for diagnosis.5 Campus Benjamin Franklin, Charite´-Universita¨tsmedizin study aimed to characterise functionally and histomor- Despite much effort over the last 40 years, for a Berlin, Germany; 2 Department phologically the diseased duodenum in human biopsies. long time it has not been possible to replicate the of Pathology/Rcis, Campus Methods: Norovirus infection was diagnosed by the Kaplan virus and only very recently are there first reports of Benjamin Franklin, Charite´- criteria and confirmed by PCR of stool samples. Duodenal viral replication in tissue culture.6 7 Therefore, Universita¨tsmedizin Berlin, Germany; 3 Robert Koch-Institut, biopsies were obtained endoscopically. In miniaturised insight into the pathophysiology of this disease is Berlin, Germany; 4 Department Ussing chambers, short circuit current, flux measurements limited. Early studies in the 1970s of experimental of Clinical Physiology, Campus and impedance spectroscopy were