stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice主机骨髓基质细胞的刺激交感神经促进小鼠乳腺癌骨转移.pdf

Stimulation of Host Bone Marrow Stromal Cells by Sympathetic Nerves Promotes Breast Cancer Bone Metastasis in Mice J. Preston Campbell1,2, Matthew R. Karolak1,2, Yun Ma2,3, Daniel S. Perrien2,4,5, S. Kathryn Masood- 2,3 6 2,3 2,7,8 1,2,3 Campbell , Niki L. Penner , Steve A. Munoz , Andries Zijlstra , Xiangli Yang , Julie A. Sterling2,3,8,9, Florent Elefteriou1,2,3,8* 1 Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America, 2 Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, Tennessee, United States of America, 3 Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America, 4 Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University, Nashville, Tennessee, United States of America, 5 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America, 6 Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, United States of America, 7 Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America, 8 Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America, 9 Department of Veterans Affairs (VISN 9), Nashville, Tennessee, United States of America Abstract Bone and lung metastases are responsible for the majority of deaths in patients with breast cancer. Following treatment of the primary cancer, emotional and psychosocial factors within this population precipitate time to recurrence and death, however the underlying mechanism(s) remain unclear.