sox genes in grass carp (ctenopharyngodon idella) with their implications for genome duplication and evolutionsox基因在草鱼(ctenopharyngodon idella)与他们的基因组复制和演化的影响.pdf

Genet. Sel. Evol. 38 (2006) 673–687 673 c INRA, EDP Sciences, 2006 DOI: 10.1051/gse:2006028 Original article Sox genes in grass carp (Ctenopharyngodon idella) with their implications for genome duplication and evolution a ,b a a ,∗ Lei Z , Xiaomu Y , Jingou T a State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, the Chinese Academy of Sciences, Wuhan 430072, P. R. China b The Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China (Received 7 February 2006; accepted 12 June 2006) Abstract – The Sox gene family is found in a broad range of animal taxa and encodes important gene regulatory proteins involved in a variety of developmental processes. We have obtained clones representing the HMG boxes of twelve Sox genes from grass carp (Ctenopharyngodon idella), one of the four major domestic carps in China. The cloned Sox genes belong to group B1, B2 and C. Our analyses show that whereas the human genome contains a single copy of Sox4, Sox11 and Sox14, each of these genes has two co-orthologs in grass carp, and the duplication of Sox4 and Sox11 occurred before the divergence of grass carp and zebrafish, which support the “fish-specific whole-genome duplication” theory. An estimation for the origin of grass carp based on the molecular