the chemokine cxcl12 is essential for the clearance of the filaria litomosoides sigmodontis in resistant mice间隙的趋化因子cxcl12至关重要的丝虫属litomosoides倍抗小鼠.pdf

The Chemokine CXCL12 Is Essential for the Clearance of the Filaria Litomosoides sigmodontis in Resistant Mice 1. ´ ´ ´ 1. 1 1 1 Tiffany Bouchery , Gaelle Denece , Tarik Attout , Katharina Ehrhardt , Nathaly Lhermitte-Vallarino , 2 2 3 3 4 Muriel Hachet-Haas , Jean Luc Galzi , Emilie Brotin , Franc¸oise Bachelerie , Laurent Gavotte , 4 1 1 Catherine Moulia , Odile Bain , Coralie Martin * ´ 1 UMR 7245 MCAM MNHN CNRS UMR 7205 OSEB MNHN CNRS, Museum National d’Histoire Naturelle, Paris, France, 2 IREBS, Biotechnologie et Signalisation Cellulaire, ´ UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Illkirch, France, 3 INSERM UMR-S 996, University of Paris-Sud 11, LabEx LERMIT, Clamart, France, 4 UMR 5554 ´ ISEM CNRS, Universite Montpellier 2, Montpellier, France Abstract Litomosoides sigmodontis is a cause of filarial infection in rodents. Once infective larvae overcome the skin barrier, they enter the lymphatic system and then settle in the pleural cavity, causing soft tissue infection. The outcome of infection depends on the parasite’s modulatory ability and also on the immune response of the infected host, which is influenced by its genetic background. The goal of this study was to determine whether host factors such as the chemokine axis CXCL12/ CXCR4, which notably participates in the control of immune surveillance, can influence the outcome of the infectio