t regulatory cells an overview and intervention techniques to modulate allergy outcomet调节细胞和干预技术概述调节过敏的结果.pdf

Clinical and Molecular Allergy BioMed Central Review Open Access T regulatory cells: an overview and intervention techniques to modulate allergy outcome 1 2 1 Subhadra Nandakumar , Christopher WT Miller and Uday Kumaraguru* Address: 1Department of Microbiology, College of Medicine, East Tennessee State University, Johnson City, TN-37614, USA and 2Division of Allergy and Immunology, Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN-37614, USA Email: Subhadra Nandakumar - microsubhi@; Christopher WT Miller - cwtmiller@.br; Uday Kumaraguru* - kumaragu@ * Corresponding author Published: 12 March 2009 Received: 1 January 2009 Accepted: 12 March 2009 Clinical and Molecular Allergy 2009, 7:5 doi:10.1186/1476-7961-7-5 This article is available from: /content/7/1/5 © 2009 Nandakumar et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Dysregulated immune response results in inflammatory symptoms in the respiratory mucosa leading to asthma and allergy in susceptible individuals. The T helper type 2 (Th2) subsets are primarily involved in this disease process. Nevertheless, there is growing evide