stem cells, inflammation and allergy干细胞,炎症和过敏.pdf

Allergy, Asthma Clinical Immunology BioMed Central Review Open Access Stem cells, inflammation and allergy Marie-Renee Blanchet* and Kelly M McNagny Address: The Biomedical Research Centre, 2222 Health Sciences Mall, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada Email: Marie-Renee Blanchet* - marierenee@brc.ubc.ca; Kelly M McNagny - kelly@brc.ubc.ca * Corresponding author Published: 7 December 2009 Received: 19 October 2009 Accepted: 7 December 2009 Allergy, Asthma Clinical Immunology 2009, 5:13 doi:10.1186/1710-1492-5-13 This article is available from: /content/5/1/13 © 2009 Blanchet and McNagny; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Recently, many studies have suggested a potential role for early hematopoietic progenitor cell and hematopoietic stem cell (HSC) recruitment and differentiation in the development of allergy and inflammation. This is based largely on evidence that stem cells or CD34+ progenitor cells are recruited to the site of inflammation in allergic diseases, likely through many of the same adhesion and chemokine receptors used for stem cell homing to the bone marrow (PSGL-1, CXCL12, alpha4-beta1 integrin, CD44, etc). Once at the site of infla