t cell activation does not drive cd4 decline in longitudinally followed hiv-infected elite controllerst细胞激活不开车cd4纵向下滑之后感染艾滋病毒的精英控制器.pdf

Kamya et al. AIDS Research and Therapy 2011, 8:20 /content/8/1/20 RESEARCH Open Access T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers 1,2 1,2,3 1,2 1,2,4 5 6 Philomena Kamya , Christos M Tsoukas , Salix Boulet , Jean-Pierre Routy , Réjean Thomas , Pierre Côté , 4 6 7 7 8 9 Mohamed-Rachid Boulassel , Bernard Lessard , Rupert Kaul , Mario Ostrowski , Colin Kovacs , Cecile L Tremblay and Nicole F Bernard1,2,3* Abstract Background: Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment. Methods: Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. + + + We assessed immune activation by measuring the percent of CD38 HLA-DR CD8 T cells in the EC group and comparing it with that in 24 treatment-naïve HIV disease progressors and 13 HIV uninfected healthy controls. Results: Compared to HIV uninfected subjects, EC had higher percentages of CD38+ + + HLA-DR CD8 T cells (p 0.001) that was lower than that observed in progressors (p 0.01). Fifteen of 25 EC had a slope of CD4 count change that was not significantly different from 0 while 3 had a positive and 7 a negative CD4 count slope. Immune activation did not distinguish EC subsets