tgf β-induced cartilage repair is maintained but fibrosis is blocked in the presence of smad7tgfβ-induced软骨修复维护但纤维化被阻塞在smad7的存在.pdf

Available online /content/8/3/R65 Vol 8 No 3 Open Access Research article TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7 Esmeralda N Blaney Davidson, Elly L Vitters, Wim B van den Berg and Peter M van der Kraan Experimental Rheumatology and Advanced Therapeutics, St. Radboud University Medical Centre Nijmegen, Geert Grooteplein 26-28, 6525 GA Nijmegen, The Netherlands Corresponding author: Esmeralda N Blaney Davidson, e.blaneydavidson@reuma.umcn.nl Received: 9 Jan 2006 Revisions requested: 3 Feb 2006 Revisions received: 23 Feb 2006 Accepted: 7 Mar 2006 Published: 29 Mar 2006 Arthritis Research Therapy 2006, 8:R65 (doi:10.1186/ar1931) This article is online at: /content/8/3/R65 © 2006 Blaney Davidson et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Cartilage damage in osteoarthritis (OA) is considered an measured by determining the synovial width and the number of imbalance between catabolic and anabolic factors, favoring the procollagen I-expressing cells. Adenoviral overexpression of catabolic side. We assessed whether adenoviral overexpression TGFβ restored the IL-1-induced reduction in PG content and of transforming growth factor-β (TGFβ) enhanced cartilage increased PG synthesis. TGFβ-induced an elevation in PG repair and whether TGFβ-induced fibrosis was blocked by local content in cartilage of