the connection between the presence of melanoma and changes in fibre diffraction patterns黑色素瘤的存在之间的联系以及纤维衍射模式的变化.pdf

Cancers 2010, 2, 1155-1165; doi:10.3390/cancers2021155 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review The Connection between the Presence of Melanoma and Changes in Fibre Diffraction Patterns Veronica J. James 1,* and Nigel Kirby 2 1 Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia 2 Australian Synchrotron, 800 Blackburn Rd Clayton, VIC 3168, Australia; E-Mail: nigel.kirby@.au * Author to whom correspondence should be addressed; E-Mail: veronica.james@.au; Tel.: +1-617 5562 2643; Fax: +1-617 5562 2543. Received: 5 May 2010; in revised form: 3 June 2010 / Accepted: 4 June 2010 / Published: 4 June 2010 Abstract: An accurate diagnosis of melanomas at an early stage correlates directly with a better prognosis. However the incidence of melanoma is still increasing along with the number of related deaths. Melanoma cells grow extremely fast, with the result that many patients present after metastasis has occurred, too late for effective treatment. This paper describes the changes in the fibre diffraction patterns of skin that indicate the presence of a melanoma. Identification of these changes would provide an alternative early low-cost, reliable diagnostic test which could be conducted on a regular basis in local radiology facilities using rotating anode X-ray generators or as a mass screening test using suitable small angle x-ray beam-lines at synchrotrons. Keywords: melanoma; diagnosis; x-r