current research and development of chemotherapeutic agents for melanoma目前化疗药物对黑色素瘤的研究和开发.pdf

Cancers 2010, 2, 397-419; doi:10.3390/cancers2020397 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Current Research and Development of Chemotherapeutic Agents for Melanoma Kyaw Minn Hsan †, Chun-Chieh Chen †, and Lie-Fen Shyur * Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan, China; E-Mail: robin@.tw (K.M.H.); maraca@.tw (C.-C.C.) † Both authors contributed equally to this article. * Author to whom correspondence should be addressed; E-Mail: lfshyur@.tw; Tel.: +886-2 Received: 25 February 2010; in revised form: 25 March 2010 / Accepted: 6 April 2010 / Published: 9 April 2010 Abstract: Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vegetables or traditional herbal medicines as alternative options or future medicine for melanoma prevention. We explore the mode of actions of these natural phytoagents against metastatic melanoma. Keywords: cutaneous malignant