the adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations成人囊性纤维化呼吸道微生物群随时间是稳定的和感染类型,和高弹性的抗生素治疗急性加重.pdf

The Adult Cystic Fibrosis Airway Microbiota Is Stable over Time and Infection Type, and Highly Resilient to Antibiotic Treatment of Exacerbations 1 . 2 3,4 3,5 2 Anthony A. Fodor * , Erich R. Klem , Deirdre F. Gilpin , J. Stuart Elborn , Richard C. Boucher , Michael M. Tunney3,4., Matthew C. Wolfgang2,6*. 1 Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America, 2 Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 3 CF and Airway Microbiology Research Group, Queen’s University Belfast, Belfast, United Kingdom, 4 School of Pharmacy, Queen’s University Belfast, Belfast, United Kingdom, 5 Center for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, United Kingdom, 6 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America Abstract Cystic fibrosis (CF) is characterized by defective mucociliary clearance and chronic airway infection by a complex microbiota. Infection, persistent inflammation and periodic episodes of acute pulmonary exacerbation contribute to an irreversible decline in CF lung function. While the factors leading to acute exacerbations are poorly understood, antibiotic treatment can temporarily resolve pulmonary symptoms and partially restore lung function. Previous studies indicated that exacerbations may be associated with changes in microbial densities and the acquisition of new microbial species. Given the compl