the gut as reservoir of antibiotic resistance microbial diversity of tetracycline resistance in mother and infant肠道抗生素耐药性的水库四环素耐药性的微生物多样性在母亲和婴儿.pdf

The Gut as Reservoir of Antibiotic Resistance: Microbial Diversity of Tetracycline Resistance in Mother and Infant 1,2 ` 3 2 4¤a ´ Lisbeth E. de Vries , Yvonne Valles , Yvonne Agersø , Parag A. Vaishampayan , Andrea Garcıa- Montaner3, Jennifer V. Kuehl4¤b, Henrik Christensen 1, Miriam Barlow5, M. Pilar Francino3,4,5* 1 Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark, 2 National Food Institute, Technical University of Denmark, Lyngby, ´ ` ´ ´ ` ` Denmark, 3 Unitat Mixta d’Investigacio en Genomica i Salut, Centre Superior d’Investigacio en Salut Publica/Universitat de Valencia-Institut Cavanilles, Valencia, Spain, 4 Evolutionary Genomics Program, Department of Energy Joint Genome Institute, Walnut Creek, California, United States of America, 5 School of Natural Sciences, University of California Merced, Merced, California, United States of America Abstract The microbiota in the human gastrointestinal tract (GIT) is highly exposed to antibiotics, and may be an important reservoir of resistant strains and transferable resistance genes. Maternal GIT strains can be transmitted to the offspring, and resistances could be acquired from birth. This is a case study using a metagenomic approach to determine the diversity of microorganisms conferring tetracycline resistance (Tcr) in the guts of a healthy mother-infant pair one month after childbirth