a plea for rational mitigation of poor outcomes in the ‘off-label use’ of medications for the management of pain论文.pdf

Journal of the Neurological Sciences 349 (2015) 72 –76 Contents lists available at ScienceDirect Journal of the Neurological Sciences j ournal homepage: /l ocate/ jns A plea for rational mitigation of poor outcomes in the ‘off-label use’ of medications for the management of pain Faraz Khursheed a, Julia Ioffe b, Harry J. Gould III a,b,c,d,e,f,⁎ a Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA, United States b Department of Internal Medicine, Section of Physical Medicine and Rehabilitation, United States c Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States d Department of Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, United States e Center of Excellence for Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA, United States f Pain Mastery Center of Louisiana, Louisiana State University Health Sciences Center, New Orleans, LA, United States a r t i c l e i n f o a b s t r a c t Article history: Neuropathic pain is a common and difficult to manage public health problem characterized by frequent Received 15 October 2014 treatment failure and high management costs. The variable presentation and response to treatment among Received in revised form 15 December 2014 patients make it difficult for physicians to apply a single, standardized approach for management. The physicians Accepted 19 December 2014