the concentration of three anti-seizure medications in hair the effects of hair color, controlling for dose and age三种抗癫痫药物的浓度在头发头发颜色的影响,控制剂量和年龄.pdf

BMC Clinical Pharmacology (2001) 1:2 /1472-6904/1/2 BMC Clinical Pharmacology (2001) 1:2 Research article The concentration of three anti-seizure medications in hair: the effects of hair color, controlling for dose and age 1 2 3 Tom Mieczkowski* , Aristidis M Tsatsakis , Michael Kruger and Thanasis Psillakis4 Address: 1Department of Criminology University of South Florida 140 Seventh Avenue South St. Petersburg, FL 33702, USA, 2Toxicology Laboratory, Dept. of Medicine, University of Crete Iraklion- Voutes, Crete, GR-71409, GREECE, 3Mott Center for Human Development College of Medicine, Wayne State University 275 Hancock, Detroit, MI 48202, USA and 4Laboratory of Toxicology, Dept. of Medicine, University of Crete Iraklion- Voutes, Crete, GR-71409, GREECE E-mail: Tom Mieczkowski* - mieczkow@; Aristidis M Tsatsakis - aris@med.uoc.gr; Michael Kruger - m_kruger@; Thanasis Psillakis - aris@med.uoc.gr *Corresponding author Published: 30 April 2001 Received: 13 March 2001 Accepted: 30 April 2001 BMC Clinical Pharmacology 2001, 1:2 This article is available from: /1472-6904/1/2 (c) 2001 Mieczkowski et al, licensee BioMed Central Ltd. Abstract Background: This paper assess the relationship between the quantity of three anti-seizure medications in hair and the color of the analyzed hair, while controlling for the effects of dose, dose duration, and patient age for 140 clinical patients undergoing anti-seizure therapy. Three drugs are assessed: carbamazepine (40 patients), valproic acid (40 patients), and phenytoin (60 patients). The relationship betw